IDEXX LaserCyte® Dx Hematology Analyzer

Comprehensive real-time results that help you provide a higher standard of care

 
  • The LaserCyte® Dx Hematology Analyzer provides you with reference laboratory-quality technology for your in-house laboratory. Get complete blood counts (CBCs), including a true five-part white blood cell differential, absolute reticulocyte count and body fluid capabilities.
  • Make more informed decisions more quickly and share results with clients during the patient visit.

 

The LaserCyte Dx Hematology Analyzer connects to the IDEXX VetLab® Station Laboratory Information Management System to provide:
  • All your diagnostic information in one comprehensive patient report
  • Access to IDEXX SmartService™ Solutions: remote troubleshooting for your IDEXX VetLab® analyzers that saves time and helps keep your laboratory running smoothly
 
LaserCyte Dx Hematology Analyzer

Accurate, comprehensive hematology results in real time

 

Benefits of the LaserCyte® Dx Hematology Analyzer include:

  • Reference laboratory-quality complete blood counts (CBCs).
  • A true five-part white blood cell differential for a full analysis of multiple characteristics on each white blood cell and an accurate interpretation of all five white blood cell types.
  • Absolute reticulocyte count to help identify the underlying cause of anemias.
  • No daily maintenance.
  • qualiBeads® are analyzed with the sample during each run to ensure the quality of the run as well as across runs to ensure the analyzer remains properly standardized.
  • Advanced Diagnostic Software, along with IDEXX’s proprietary, patent-pending, veterinary-specific algorithm ensures the integrity of the optics by returning them to the factory settings. Read more about performance and reliability. (PDF)
  • Single-sample reagents and onboard mixing system reduces user training requirements—sample aspiration is totally automated.
  • Early platelet aggregates are broken up for accurate platelet counts.
  • Fully validated species menu and 24 hematology parameters.
  • Closed-tube sample processing means no sample preparation and no contamination.

 

Dot Plots

Dot plots are a visual representation of the complete blood count (CBC); each dot represents a single cell. Dot plots are a critical element of the CBC, providing a snapshot of cellular morphology. Only the LaserCyte® Dx Hematology Analyzer and the ProCyte Dx® Hematology Analyzer provide these valuable tools.

 

Red Blood Cell Classification

White Blood Cell Classification

 

View the LaserCyte Dx Hematology Analyzer: Case Study Book and Technical Guide (PDF) for detailed information on the LaserCyte Dx Hematology Analyzer, including case studies, dot plots, and laser flow cytometry technology.

 

Laser Flow Cytometry

The LaserCyte® Dx Hematology Analyzer uses reference laboratory technology to analyze blood samples. The analyzer focuses a laser beam on each individual cell and quantifies the scatter of light on four separate detectors.

Simultaneously, the analyzer measures the amount of time it takes a cell to travel through the laser beam. This cell travel time is referred to as the “time of flight” and it provides data on the diameter of the cell.

Example:
Think of a flashlight as an analogy for the laser. Passing a golf ball in front of the light is quicker than passing a basketball through the same light.

While the time of flight, or cellular diameter, is being measured, four other detectors are measuring the quantity of light bouncing off the ball.

The dimpled design of a golf ball will refract light differently than the seamed design of a basketball. Therefore, in this analogy, the golf ball would be classified as a different “cell” from the basketball.

The four detectors quantify the scatter of light from each cell to measure size, complexity, granularity and light absorption—the same qualities a pathologist would examine when looking at a blood film.

Laser Flow Cytometry Diagram

The LaserCyte Dx Hematology Analyzer provides the data needed for a more complete diagnosis because it can:

  • Analyze red blood cells
  • Identify the reticulocytes and generate an absolute reticulocyte count
  • Identify all five types of white blood cells

Advantages of laser flow cytometry

  • Because a laser flow cytometry-based analyzer evaluates multiple characteristics (nuclear and cytoplasmic material) of red blood cells, white blood cells and platelets, it produces more accurate and reliable counts than other systems.
  • Clumped platelets can be detected and flagged.
  • Large platelets (frequently encountered in cats) can be distinguished from erythrocytes due to difference in the scatter of light caused by the platelet granules.
  • Laser flow cytometry-based analyzers are able to rapidly count large numbers (>200,000) of erythrocytes, which are needed to produce accurate and repeatable reticulocyte counts.

 

 

Accuracy verified

 

To ensure the trusted hematology results you need, we partnered with Purdue University, the University of Florida, Tufts University and Michigan State University to compare the performance of the LaserCyte Dx Hematology Analyzer to the ProCyte Dx® Hematology Analyzer.

The following graphs compare the results obtained using two LaserCyte Dx analyzers and a ProCyte Dx analyzer at the University of Florida. The data includes canine, feline and equine samples (totaling 100 of each species split across the two LaserCyte Dx analyzers). These results indicate good correlation between the LaserCyte Dx and the ProCyte Dx for canine, feline and equine samples.1

 

Reference
1.
Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.

 

View the LaserCyte Dx Analyzer: Case Study Book and Technical Guide (PDF) for detailed information on the LaserCyte Dx analyzer, including case studies, dot plots, and laser flow cytometry technology.

 

LaserCyte Dx Analyzer Specifications

Parameters (24) Hct, RBC, Hgb, MCV, MCH, MCHC, RDW, reticulocytes (absolute number and percentage), WBC, neutrophils (number and percentage), lymphocytes (number and percentage), monocytes (number and percentage), eosinophils (number and percentage), basophils (number and percentage) and platelets (number, MPV, PDW and PCT)
Units Conventional or SI units
Sample Size 95 µL of sample with EDTA anticoagulant is used per evaluation (500 µL of sample in a 13 mm x 74 mm VetCollect® Tube is required)
Time to Results The LaserCyte Dx analyzer will return resutls in approximately 10 minutes.
Reagents The LaserCyte Dx CBC5R Test Kit includes 50 CBC5R tubes, 50 VetCollect 1-mL draw sample collection tubes, one tube of enzymatic wash solution, one discard tube and two bottles of sheath reagent.
Calibration Performed at IDEXX. Lot-specific reagent information is bar-coded onto each consumable tube.
Internal Standard Each CBC5R tube has a set number of qualiBeads®. qualiBeads are known particles with specific characteristics that are used by the analyzer as an internal standard to verify pipetting accuracy and laser performance.
Sample Flow Cell 250-micron quartz cuvette using focused-flow hydrodynamics to create a single-cell stream
Operating Temperature Instrument 15º–27ºC (60º–80ºF)
Dimensions LaserCyte Dx analyzer: width x depth x height = 34 x 36 x 33 cm
Net Weight LaserCyte Dx analyzer: 8 kg (17 lb)

LaserCyte® Dx Hematology Analyzer Parameters

The LaserCyte® Dx Hematology Analyzer offers a full menu of hematology parameters and prints all your IDEXX VetLab® in-house analyzer results in one comprehensive report. The report provides a complete picture of your patient's health status and facilitates face-to-face communication with clients.

Results are validated for five species (canine, feline, equine, pig and ferret) across 24 different parameters.* Simple, intuitive flagging highlights questionable results, like clumped platelets or abnormal white blood cell patterns, to indicate the need for further investigation, including review of the blood film. Other species capabilities are available.

Parameter Description
HCT (hematocrit) With every report
RBC (red blood cell count)
  • A vital supplement to the HCT
  • Accurate measurements allow accurate calculations of MCH and MCHC.
HGB (hemoglobin) With every report
RETIC (reticulocyte count and percentage of reticulocytes) Reticulocytes are essential and the gold standard for characterizing if an anemia is regenerative or nonregenerative.
MCV (mean cell volume)
  • Serial accurate measurement allows better following of the progression or regression of a disease state
  • Serial measurements on yearly health checkups could prove helpful in early disease detection, such as chronic blood loss
RDW (red blood cell distribution width)
  • Objective measurement of variation in size of red blood cells (anisocytosis)
  • Allows the veterinarian to better follow the progression and regression of a disease
MCHC (mean cell hemoglobin concentration) With every report
MCH (mean cell hemoglobin) With every report
PLT (platelet count) The LaserCyte Dx Hematology Analyzer’s laser flow cytometry offers a much more accurate platelet count than impedance-only counters
MPV, PDW, PCT (mean platelet volume, platelet distribution width, platelet hematocrit) Aid in the characterization of a platelet abnormality (such as presence or absence of a bone marrow response to a peripheral demand for platelets)
WBC (white blood cell count) With every report
Monocytes and Lymphocytes (% and #)
  • Help identify inflammatory diseases where macrophages are a significant component of the inflammatory process
  • Differentiation of monocytes and lymphocytes helps accurately identify the presence of an underlying glucocorticoid influences (stress, steroid administration, hyperadrenalcorticism, etc.)
Neutrophils (% and #) Important in identifying certain types of inflammatory disease and their severity, as well as following the progression or regression of inflammation
Eosinophils (% and #)
  • Important in identifying systemic hypersensitivity, which can be caused by heartworm, flea bite dermatitis, feline asthma, allergic gastroenteritis and more
Basophils (% and #) May be helpful in identifying systemic hypersensitivity, as well as acute allergic reactions
 
Fluid Analysis The ability to run body-fluid analyses for real-time cell counts and assistance in fluid classification
TNCC (total nucleated cell count) A count of all nucleated cells in a fluid, including white blood cells, nucleated red blood cells and both benign and malignant somatic cells, such as mesothelial cells, epithelial cells, etc.
Granulocyte (# and %) Nucleated cells including all three granulocyte populations: neutrophils, eosinophils and basophils
Agranulocyte (# and %) Nucleated cells including all nucleated cells not included in the “granulocyte” category: lymphocytes, monocytes, macrophages, mesothelial cells, neoplastic cells, etc.
RBC (red blood cell count) A count of all non-nucleated red blood cell forms

 

*The number of reported parameters may vary according to species.

 

Unprecedented ease-of-use

 

Run a test in just three simple steps.
  1. Place the sample and CBC5R tubes in the LaserCyte® Dx analyzer.
  2. Enter the client and patient information on the IDEXX VetLab® Station.
  3. Tap the Run button and walk away.

That’s it!
Results are ready in just minutes for next steps and sharing
with clients during the patient visit.

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