Coag Dx™ Analyzer
Avoid bleeding complications—uncover clotting disorders in seconds
The Coag Dx™ Analyzer connects to the IDEXX VetLab® Station, a laboratory information management system that collects all results into an electronic medical record and prints them on an integrated report for easy interpretation.
Detect clotting disorders immediately for the most successful treatment
- Provides results immediately—when you need them the most
- Performs aPTT, Citrate aPTT, PT and Citrate PT tests
- Uses fresh or citrated whole blood
- Designed and validated for veterinary use on canine, feline and equine patients*
- Uses end point fibrin clot detection technology, which is the gold standard
- Tests abnormalities in intrinsic, extrinsic and common pathways
- Sends results to the IDEXX VetLab® Station allowing for one seamless report containing all test results for a patient
- Includes IDEXX Customer Support and free consultations with IDEXX pathologists and internists
Equine: PT and Citrate PT
Designed for ease of use and reliability
The Coag Dx™ Analyzer measures whole blood clotting times using disposable single-use Coag Dx™ Cartridges. Each cartridge contains all of the reagents necessary for a specified test.
- The analyzer measures the required volume of blood and mixes the blood with reagents contained in the cartridge. The remaining sample not needed for testing is automatically drawn out of the sample well and into an enclosed waste channel on the cartridge.
- After mixing with the reagent, the sample is moved back and forth at a predetermined rate within the test channel and monitored for clot formation.
The rate of movement of the sample is monitored by a series of LED optical detectors that are aligned with the test channel. When the blood clots, the flow of the blood sample within the test channel is impeded, reducing its rate of flow. This reduction in flow between the optical detectors signals to the analyzer that a clot has formed.
- The analyzer emits an audible beep, indicating the end of the test. The test results remain on the display as long as the cartridge remains in the analyzer.
When connected to the IDEXX VetLab Station or an external printer, results can be automatically printed along with the time and date the test was run, the Patient ID, Client ID and other information, if entered.
Results are also saved in an internal database. Up to 600 patient test results and 600 quality control test results can be stored in the analyzer for later printing or downloading.
IDEXX Coag Dx Analyzer Specifications
IDEXX Coag Dx™ Analyzer Tests
Activated Partial Thromboplastin Time test to screen for intrinsic and common coagulation pathway disorders. For use with fresh whole blood. Validated for canine and feline use.
Activated Partial Thromboplastin Time test to screen for intrinsic and common coagulation pathway disorders. For use with citrated whole blood. Validated for canine and feline use.
Prothrombin Time test to screen for extrinsic and common coagulation pathway disorders. For use with fresh whole blood. Validated for canine, feline and equine use.
Prothrombin Time test to screen for extrinsic and common coagulation pathway disorders. For use with citrated whole blood. Validated for canine, feline and equine use.
When and how to use the Coag Dx™ Analyzer
Testing fresh citrated whole blood samples
A suggested protocol for coagulation assessment:
Events that lead to the formation of a blood clot are simplified in coagulation theory into two interactive coagulation cascades that are referred to as the intrinsic and the extrinsic pathways, both leading to the common pathway and the formation of a stable fibrin clot.
Activated Partial Thromboplastin Time (aPTT and Citrate aPTT) and Prothrombin Time (PT and Citrate PT) tests are general coagulation screening tests that are used to measure the functionality of the blood coagulation cascade.
Coag Dx™ Analyzer questions and answers
Bleeding disorders are abnormalities in the hemostasis process (i.e., the formation of a blood clot). Primary bleeding disorders involve platelet disorders, including thrombocytopenia and thrombopathies as well as von Willebrand’s disease and vasculopathies. Secondary bleeding disorders are due to diseases involving coagulation factors. Bleeding disorders can be either acquired or inherited. The important thing to note about bleeding disorders is that they can occur in any animal at any time.
Hemostasis is the process of maintaining blood in its fluid state while stopping bleeding in cases of trauma or disease. It’s the balance between the formation of blood clots to stop bleeding (or hemorrhage) from injured blood vessels and the prevention of clot formation (or thrombosis) beyond the site of vessel injury. Too little hemostasis results in hemorrhage while too much hemostasis results in thrombosis. When hemostasis is in balance, rapid clotting at the site of injury and appropriate healing occur. Hemostasis is classically divided into:
- Primary hemostasis, which results in the formation of a temporary platelet plug.
- Secondary hemostasis, which results in the formation of a stable fibrin plug.
- There are also anticoagulant and fibrinolytic components that limit the extent of clot (or thrombus) formation and facilitate its breakdown.
Coagulation factors are proteins that are primarily produced by the liver. Just like platelets, they circulate in the plasma in an inactive form when not needed. When activated, coagulation factors interact to form a stable fibrin clot resulting in coagulation. The coagulation cascade is divided into an intrinsic pathway and an extrinsic pathway, both of which merge into a common pathway. All three of these pathways are important in understanding normal clotting mechanisms. The IDEXX Coag Dx Analyzer helps identify deficiencies in all three pathways and can help indicate if a more permanent fibrin clot will form to stop bleeding.
Laboratory tests are essential to characterize a bleeding disorder. These tests should be interpreted together with a patient’s history, physical exam and clinical findings. Blood samples for these tests should be collected atraumatically and prior to the initiation of therapy.
- Tests for primary bleeding disorders include:
- CBC (platelet assessment) and blood film
- von Willebrand’s Factor
- Buccal Mucosal Bleeding Time
- Tests for secondary bleeding disorders include:
- aPTT (Activated Partial Thromboplastin Time)
- PT (Prothrombin Time)
- Thrombin Time
- ACT (Activated Clotting Time)
Both aPTT (activated partial thromboplastin time) and ACT (activated clotting time) tests assess the intrinsic and common pathways. When compared to the aPTT, the ACT test is less sensitive to intrinsic and common pathway problems. If a hemostatic problem is suspected and ACT is “normal,” an aPTT test should be performed. ACT can potentially be prolonged by thrombocytopenia, while the aPTT test is not affected by low platelet numbers.
Proper technique for blood collection is essential for accurate results. Blood should be drawn as atraumatically as possible in a syringe or a blue-top (sodium citrate) tube. Samples with visible clotting or debris should be discarded and a fresh sample obtained. The Coag Dx Analyzer can analyze both fresh and citrated whole blood samples. The fresh blood should be analyzed immediately using the fresh whole blood PT/aPTT cartridges. The citrated blood should be analyzed within 2 hours using the citrated whole blood PT/aPTT cartridges.
The Coag Dx Analyzer can immediately provide important information regarding the blood clotting status of a patient, which is when veterinarians need it. Clinics use the Coag Dx Analyzer for:
- Presurgical or procedure workup (e.g., liver biopsies) for at-risk animals
- Clinical signs of excessive bleeding
- Rat poisoning and other toxins
- Disseminated Intravascular Coagulopathy (DIC)
- Severe systemic disease (e.g., neoplasia)
- Monitoring therapy and disease progression
The following four tests, which are validated for canine and feline use, can be run on the Coag Dx and the SCA2000 analyzers:
- Prothrombin Time (PT), for use with fresh whole blood
- Activated Partial Thromboplastin Time (aPTT), for use with fresh whole blood
- Citrate Prothrombin Time (PT), for use with citrated whole blood
- Citrate Activated Partial Thromboplastin Time (aPTT), for use with citrated whole blood.
The PT and Citrate PT tests are also validated for equine use.
The Coag Dx Analyzer automatically performs daily internal electronic and temperature quality control testing to verify performance. The analyzer also performs a system check every time it is activated and a test is performed.
Yes, the Coag Dx Analyzer inserts provide feline, canine and equine normal reference intervals for each test. These reference ranges were evaluated by clinical trials for this analyzer. The IDEXX VetLab® Station report will also include the normal reference intervals for the coagulation tests.
Yes, the Coag Dx Analyzer does connect to the IDEXX VetLab Station via an ethernet connection. Customers will need a router to connect the Coag Dx Analyzer to the IDEXX VetLab Station, which will be provided by IDEXX.
While many animals can be tested using the Coag Dx Analyzer, it has only been validated for the following species:
- Canine and feline species: PT, Citrate PT, aPTT, Citrate aPTT
- Equine species: PT, Citrate PT
Yes. The IDEXX consumable can be used with both the IDEXX Coag Dx and SCA2000 analyzers.
No, the SCA2000 analyzer does not connect to the IDEXX VetLab Station.
While IDEXX is not an authorized SCA2000 service center and cannot service these analyzers, IDEXX will work with the manufacturer on the customer’s behalf to resolve any warranty- and service-related issues.
IDEXX will offer rebate programs for SCA2000 users to trade up to a Coag Dx Analyzer.
Each of the components is an integral part of the IDEXX in-house laboratory for veterinary practices.
Small, lightweight and quiet high-speed centrifuge that spins blood in two minutes or less.
Superior ELISA technology, trusted by thousands of veterinarians and clinics worldwide.